Disney animation head John Lasseter is the one to leave the studio, months after staff accused him of misconduct.
Toy Story director was starting from the month of November, after it emerged that he had made people feel uncomfortable with what he termed “unwanted hugs”.
Mr. Lasseter told to leave Disney by the end of the year to focus on “new creative challenges”.
Allegations of sexual misconduct have prompted the resignation of many public figures, in the course of the past year.
A deluge of complaints that it has triggered after Hollywood producer Harvey Weinstein has been accused of harassment and aggression on the part of many women.
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The allegations against Mr Lasseter has emerged in an investigation by The Hollywood Reporter magazine, who described a “pattern of alleged misconduct detailed by the Disney/Pixar insiders”.
At the time, Mr. Lasseter has issued an apology for his “false steps” for those who “has always been on the receiving end of an unwanted hug”, adding that his intent was “benign”.
Other sources stated that he was known for the capture, kissing, making comments”. He has always denied wrongdoing.’Sabbatical’
Announcing his permanent departure on Friday, he said: “The last six months have provided an opportunity to reflect on my life, career, and personal priorities.
“I decided [that] the end of this year is the right time to start focusing on new creative challenges.”
Disney has said that after his six-month “sabbatical”, Mr. Lassiter to retain a “consulting role” at the company until his departure.
Mr. Lasseter joined Disney in 2006, when the studio bought Pixar, which he co-founded.
In addition to directing the 1995 hit Toy Story, he is the creative force behind A bug’s Life, Cars, finding Nemo, Wall-E, Up, and Frozen.
The Weinstein scandal inspired #MeToo and similar social media movements around the world of the victims of sexual harassment or abuse.
At the beginning of this month, Mr Weinstein pleaded not guilty to the charges of rape and other sexual offences.