“Chemical embryo surgery” removes disease

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Precise “chemical surgery” was performed to remove the use of human embryos, the disease in a world first, Chinese researchers have told the BBC.

The team of the Sun Yat-sen University used a technique called a base edit to correct a single error, out of the three billion “letters” of our genetic code.

They changed the lab to remove made embryos, the disease is beta-thalassemia, which is not implanted.

The team says the approach may one day treat a range of hereditary diseases.

The Basis of the editing changed the fundamental building blocks of DNA: the four bases adenine, cytosine, guanine, and thymine.

They are commonly known by their respective letters, A, C, G and T.

All the instructions for the construction and operation of the human body the combinations of the four bases are encoded.

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The potentially life-threatening blood disease, beta-thalassemia is caused by a change in a single base in the genetic code known as a point mutation.

The team in China edited it.

They scanned the DNA for the error, which then results in a G to A, the correction of the error.

Junjiu Huang, one of the researchers, told the BBC News website: “We are the first to demonstrate the feasibility of the cure of genetic diseases in human embryos of the base editor system.”

He said, their study opens new avenues for the treatment of patients and the prevention of babies are born with beta-thalassemia “, and also other hereditary diseases”.

The experiments were conducted in tissue of a patient with a blood disease, and in human embryos by cloning. Genetics-revolution

The starting point of the processing is a advance on a form of gene editing known as Crispr, is the science revolutionized.

Crispr breaks in DNA. To repair when the body tries to break it disables a set of instructions, called genes. It is also an opportunity to place new genetic information.
To stop the use of human embryos processed disease
British scientists edit the DNA of human embryos

Basic editing work on the DNA-to convert bases itself in another.

Prof David Liu, the pioneering work base editing at Harvard University, describes the approach as “chemical intervention”.

He says the technology is more efficient and has less unwanted side effects as Crispr.

He told the BBC: “About two-thirds of the known human genetic variants associated with the disease-point mutations.

“So the base revision is the potential to correct, directly or not to reproduce has, for the purposes of research, many pathogens [mutations].”

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The research group at Sun Yat-sen University in Guangzhou in the headlines before, when you were the first, the Crispr on human embryos.

Professor Robin Lovell-Badge, from the Francis Crick Institute in London, described, parts of your most recent study as “awesome”.

But he, too, asked the question, why are you not using animals in research before jumping on human embryos and said that the rules would have been to research on embryos in other countries, “demanding”.

The study, published in the Protein and cell, is the latest example of the rapidly growing ability of scientists to manipulate human DNA.

It is provocative, deep ethical and societal debate about what is and is not acceptable to prevent the efforts of the diseases.

Prof Lovell-Badge said, these approaches are unlikely to be clinically applied quickly at any time.

“It’s a lot more discussion, which should be governed by ethics, and how these approaches should.

“And in many countries, including China, it needs more robust mechanisms for the regulation, supervision and long-term follow-up.”

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